Archive for the 'Diabetes' Category
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Yazan: admin | 03 September 2008 | No Comments
Categories: Diabetes
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. Resveratrol, a polyphenolic SIRT1 activator, mimics the anti-ageing effects of calorie [...]
